SUMMARY

Preventing Alzheimer’s disease (AD) and related dementias is a global priority—yet no new drugs have been approved since 2002, and most of the drugs available today do not do much to change the progression of the disease. However, multi-modal preventive treatments that simultaneously target several disease mechanisms and risk factors show great promise. In particular, the lifestyle-based, multi-dimensional Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) addresses nutrition, physical exercise, cognitive training, and vascular/metabolic risk management, and it has shown significant cognitive benefits in at-risk older adults in a large-scale, long-term randomized control trial.

World-Wide FINGERS (WW-FINGERS) aims to adapt and expand the FINGER model to countries around the world, building the first global network of multimodal dementia-prevention trials. This network will give researchers around the world the opportunity to harmonize, adapt, and share data and analyses across trials and sites.

WW-FINGERS’ approach to dementia-prevention trials can lay the groundwork for the development of better treatments for AD.

World-Wide FINGERS (WW-FINGERS) aims to adapt and expand the FINGER model to countries around the world, building the first global network of multimodal demential-prevention trials.

APPROACH

WW-FINGERS will assess the efficacy of multi-modal interventions to slow or prevent cognitive decline and dementia. It will also help close the significant research gaps in the field by establishing a rich global data repository along with protocols and infrastructure for data alignment, harmonization, and sharing.

ADDI is supporting WW-FINGERS’ efforts to help researchers harmonize and share the data their individual studies generate, facilitating an interoperable data architecture that enables joint analyses and comparisons across studies and sites.

Date 07.07.2020
Lead Researcher Miia Kivipelto
Institution FINGERS Brain Health Institute
Grant Type Project
Duration 1-year pilot