Emory GNPC Longitudinal Study with Plasma and Proteomic Data
The Emory Goizueta Global Neurodegeneration Proteomics Consortium (GNPC) Plasma and Proteomics dataset provides data from an observational longitudinal study of Alzheimer’s disease and related dementia
The dataset was produced by the Goizueta Alzheimer’s Disease Research Center (GADRC), part of the Emory Goizueta Brain Health Institute as part of their participation in the GNPC Data Challenge.
Hosted by the Alzheimer’s Disease Data Initiative (AD Data Initiative), the GNPC Data Challenge invited scientists to explore the GNPC Harmonized Dataset V1—the largest proteomics dataset available for neurodegenerative diseases. The AD Data Initiative hosted the challenge to accelerate breakthroughs in Alzheimer’s research through open science and data-driven collaboration.
This dataset is one of several cohort contributions to the challenge, alongside Bio-Hermes-001, Answer ALS, University of Kansas Alzheimer's Disease Research Center (KU ADRC) - Global Neurodegeneration Proteomics Consortium (GNPC), and Mayo Clinic Study of Aging (MCSA), that make up the broader GNPC Harmonized Dataset v1.
What the Dataset Contains
The dataset contains:
- 493 individuals, 762 total plasma samples
- 269 longitudinal samples, supporting within-subject change analysis over time
- Proteomic profiling via SomaScan v4.1 7k platform
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What Researchers Can Do With This Dataset
This dataset supports research into plasma-based biomarker discovery, longitudinal protein expression changes across disease stages, and cross-cohort validation of proteomic signatures associated with Alzheimer's disease. The dataset's longitudinal structure makes it useful for researchers studying how protein markers shift as disease progresses.
How to Access The Dataset
The dataset is accessible through AD Workbench, a secure, cloud-based research environment, at no cost to qualified researchers. Registration connects researchers to this dataset alongside hundreds of others in the AD Discovery Portal catalogue, supporting cross-cohort and multimodal analysis.
The Emory Goizueta GNPC Plasma and Proteomics dataset is discoverable through the AD Discovery Portal and accessible within individually permissioned AD Workbench workspaces at no cost to qualified researchers. AD Workbench provides free compute, virtual machines, and multimodal analysis tools and allows researchers to bring their own code, models, and approved external datasets into their workspace.