Over two decades, the field has established that sex and gender influence ADRD risk, biology, diagnosis and clinical outcomes — yet research infrastructure does not consistently account for them. Those gaps affect the validity and reach of findings across all ADRD research, and closing them takes a coordinated, large-scale approach no single lab or funder can achieve alone.

Supported by the AD Data Initiative, S|GN is building an integrated, sex- and gender-informed research ecosystem in three phases: aggregate, harmonize and analyze existing data; generate targeted new data where gaps remain; and expand cohort participation across institutions and geographies.