The NeuroToolKit

The NeuroToolKit (NTK) is a collaborative initiative across academia, industry and philanthropy partners to generate high quality, reproducible and comparable biomarker data. Together, the NTK partners aim to advance research and inform developments in diagnostic and treatment solutions in AD, neurodegeneration and other neurological disorders.

The NTK aims to advance research through

(i) the generation of high-quality biomarker data via the fully automated Elecsys® platform;

(ii) a digital research environment using the NTKApp, which is fully integrated on ADDI’s AD Workbench.

The NTK is an innovative approach to accelerate the validation of biomarkers for clinical utility and the best-in-class tool for collaborative data analysis; the purpose of the measurements is not clinical decision-making.

Vision

  • Unify the neurology field to accelerate the validation of integrated biomarker testing solutions for patients with neurological disorders.

Mission

  • Enable the development of the neurology field through a unique ecosystem of partnerships, biomarkers and collaborative data science.

Timeline

Categories

Robust Prototype Assay Portfolio

The NTK offers an intended-use agnostic portfolio of 14 CSF and 16 serum/plasma assays, with more in development.

The NTK assays can be run on the fully automated Elecsys® platform in four NTK qualified labs. This ensures that high quality, reproducible data can be compared to multiple datasets, thus maximizing how results can be interpreted.

NTKApp

The NTKApp is a powerful, cloud based, fully integrated analytics platform. It improves the process and ability to interpret neurologically relevant immunoassay data while providing users a unified, cloud-based platform. The NTKApp consists of three interlinked apps to upload, curate, analyze, and compare biomarker datasets and results. Thanks to the NTKApp built-in virtual machine, we offer the option to import, shape, and run your own statistical analysis pipeline that can later be shared with the NTK community. The NTKApp is a new tool to exchange new ideas, encourage valuable research, and support industry partnerships – all to accelerate biomarker discovery and development.

How to become a partner

If you are interested in joining the NTK project, please reach out to:

Margherita Carboni (margherita.carboni@roche.com), Clinical Development Lead

Karolina Jarawka (karolina.jarawka@roche.com), Director Partenering

After your request is evaluated, you will have to sign an NTK collaboration agreement, including a material transfer agreement with the designated NTK testing site.

A fee per determination (one sample measured with one biomarker) is charged per cohort. This covers all costs, including reagents and lab fees.

If you have any generic requests or questions about the NeuroToolkit, please reach out to neurotoolkit@roche.com.

Publications

2023
2022
2021
2020

FAQ's

What is the NeuroToolKit (NTK)?
Which biomarkers are included?
What is the sample volume needed for NTK measurements?
What is the intended use of the NTK?
How are these biomarkers related to Alzheimer's Disease (AD)?
How are these biomarkers related to other types of neurodegenerative diseases?
How do we compare data / results generated with the NTK assays?
How do I become a member of the NTK community?
Can I set up an NTK assay analysis at my site?

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